https://dosa-diagnostics.org dosa-diagnostics Mon, 23 Nov 2020 17:16:05 +0000 https://dosa-diagnostics.org en https://dosa-diagnostics.org/Introduction Sun, 20 Jan 2019 18:55:56 +0000 dosa-diagnostics https://dosa-diagnostics.org/Introduction <img width="1876" height="872" width_o="1876" height_o="872" data-src="https://freight.cargo.site/t/original/i/e4cb03a6ae23cc8d9bf4029cd59c04e9c70e95603f9f45bc3298708b0392d0b4/intro3-03.png" data-mid="40850867" border="0" src="https://freight.cargo.site/w/1000/i/e4cb03a6ae23cc8d9bf4029cd59c04e9c70e95603f9f45bc3298708b0392d0b4/intro3-03.png" /> <img width="1805" height="347" width_o="1805" height_o="347" data-src="https://freight.cargo.site/t/original/i/176d8e14bdc0789926e702086d38f14a6406397bba323bb9432a8bbb38c623dc/newintro-05-02.png" data-mid="33955804" border="0" data-scale="76" src="https://freight.cargo.site/w/1000/i/176d8e14bdc0789926e702086d38f14a6406397bba323bb9432a8bbb38c623dc/newintro-05-02.png" /><img width="1875" height="1043" width_o="1875" height_o="1043" data-src="https://freight.cargo.site/t/original/i/82f8edf34cbdcd9d96c6731e1d952ffb45df270554b603fae05e7973bf3e0980/intro2-01.png" data-mid="39985542" border="0" data-scale="69" src="https://freight.cargo.site/w/1000/i/82f8edf34cbdcd9d96c6731e1d952ffb45df270554b603fae05e7973bf3e0980/intro2-01.png" /> <img width="865" height="721" width_o="865" height_o="721" data-src="https://freight.cargo.site/t/original/i/de55763aa0d6eeae412dfdaf1d0492c43c6c211759b5126cc6e495c1bdd59bee/logo2.png" data-mid="39985715" border="0" data-scale="12" src="https://freight.cargo.site/w/865/i/de55763aa0d6eeae412dfdaf1d0492c43c6c211759b5126cc6e495c1bdd59bee/logo2.png" />&nbsp;&nbsp;<img width="822" height="303" width_o="822" height_o="303" data-src="https://freight.cargo.site/t/original/i/94cbd8d2d650f6c3351f7c64208edc906c0b5244441a9a515d18b1f8aace1b3b/DBT-logo.png" data-mid="41110007" border="0" data-scale="27" src="https://freight.cargo.site/w/822/i/94cbd8d2d650f6c3351f7c64208edc906c0b5244441a9a515d18b1f8aace1b3b/DBT-logo.png" /> https://dosa-diagnostics.org/About-2 Sun, 20 Jan 2019 18:55:54 +0000 dosa-diagnostics https://dosa-diagnostics.org/About-2 <img width="5184" height="1085" width_o="5184" height_o="1085" data-src="https://freight.cargo.site/t/original/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" data-mid="34491676" border="0" src="https://freight.cargo.site/w/1000/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" /> &nbsp;About&nbsp;The DOSA Project (Diagnostics for One health and user driven Solutions for Anti-microbial resistance) is an interdisciplinary research project which brings together nine leading academic institutions, five from India and four from the UK. The project will develop innovative diagnostics to curb antimicrobial resistance (AMR) which is one of the biggest threats to global public health. AMR describes the situation when infectious agents such as bacteria are becoming resistant to the medicines used to treat them. DOSA will involve diagnostic innovators, medical researchers, economists, design researchers and social scientists to create cutting edge, rapid diagnostic solutions to fight AMR in community healthcare, dairy and aquaculture settings in India. This work is also being seen as an opportunity to build capability and capacity in the use of social science and user centred design research approaches to tackle AMR in India. AMR is a major public health concern in India with high levels of resistance across multiple pathogens and even affecting newer and more expensive drugs, such as carbapenems. Contributing factors to the increase of AMR in India are complex and include inappropriate and over use in humans and animals. Rapid diagnostics are considered essential tools in the fight against AMR but they are either unavailable, too expensive or do not fit the needs of people who want to use them. For these reasons, DOSA engages intensely with users in the three settings to better understand their needs, the current antibiotic use and AMR situation and co-design diagnostic solutions which are addressed by the diagnostic innovator teams in DOSA. The project is jointly funded by UK Research and Innovation Economic and Social Research Council, the Newton Fund, and Government of India’s Department of Biotechnology. Our partners include: Click logo to find out more <img width="200" height="213" width_o="200" height_o="213" data-src="https://freight.cargo.site/t/original/i/2c74839ada0f09ddc88c706c7f455682ba9664cafa3fdea503671cd55d22c72b/assam.png" data-mid="33917574" border="0" data-scale="10" src="https://freight.cargo.site/w/200/i/2c74839ada0f09ddc88c706c7f455682ba9664cafa3fdea503671cd55d22c72b/assam.png" /> <img width="225" height="225" width_o="225" height_o="225" data-src="https://freight.cargo.site/t/original/i/02109e8d1166f2c2a1b713e5b81835f08f5af9e03a7cb2085b99eccf31694096/CIFT.jpg" data-mid="33917576" border="0" data-scale="10" src="https://freight.cargo.site/w/225/i/02109e8d1166f2c2a1b713e5b81835f08f5af9e03a7cb2085b99eccf31694096/CIFT.jpg" /> <img width="215" height="220" width_o="215" height_o="220" data-src="https://freight.cargo.site/t/original/i/fdcb912db08434c040698ae57a3b5957bbf8b7cd9514cf0d4b2be687040fb57a/ndri.png" data-mid="33917578" border="0" data-scale="10" src="https://freight.cargo.site/w/215/i/fdcb912db08434c040698ae57a3b5957bbf8b7cd9514cf0d4b2be687040fb57a/ndri.png" /> <img width="224" height="225" width_o="224" height_o="225" data-src="https://freight.cargo.site/t/original/i/a6ca8df03b9a7e3504e5929db6afffac2c1e9686d9fc925b316bf303ec89689a/UOE.png" data-mid="33917582" border="0" data-scale="10 " src="https://freight.cargo.site/w/224/i/a6ca8df03b9a7e3504e5929db6afffac2c1e9686d9fc925b316bf303ec89689a/UOE.png" /> <img width="220" height="165" width_o="220" height_o="165" data-src="https://freight.cargo.site/t/original/i/c0aca5016c359620593825199a45ba17903afe2e2601a1de5f6c3b1c807d8308/iitd.jpg" data-mid="33917577" border="0" data-scale="13" src="https://freight.cargo.site/w/220/i/c0aca5016c359620593825199a45ba17903afe2e2601a1de5f6c3b1c807d8308/iitd.jpg" /><img width="205" height="246" width_o="205" height_o="246" data-src="https://freight.cargo.site/t/original/i/21944759b5b28679838d376702d053d0717b9843957abd37c7c91aca2a94f91b/SMC.jpg" data-mid="33917579" border="0" data-scale="8" src="https://freight.cargo.site/w/205/i/21944759b5b28679838d376702d053d0717b9843957abd37c7c91aca2a94f91b/SMC.jpg" /> &nbsp;<img width="339" height="149" width_o="339" height_o="149" data-src="https://freight.cargo.site/t/original/i/2b005f87951e3a73d9b32344df9281ebc7d8673da1485483e0cda5f68c705190/CAMP.jpg" data-mid="33917575" border="0" data-scale="20" src="https://freight.cargo.site/w/339/i/2b005f87951e3a73d9b32344df9281ebc7d8673da1485483e0cda5f68c705190/CAMP.jpg" /> <img width="800" height="202" width_o="800" height_o="202" data-src="https://freight.cargo.site/t/original/i/e5c3072c6c13a39e654bb7ea7aa4e79525a9cc4771c382bd7c8ad1f76d58a363/uob_logo_rgb_positive_large.jpg" data-mid="38992033" border="0" data-scale="21" src="https://freight.cargo.site/w/800/i/e5c3072c6c13a39e654bb7ea7aa4e79525a9cc4771c382bd7c8ad1f76d58a363/uob_logo_rgb_positive_large.jpg" />&nbsp; &nbsp; &nbsp;<img width="1280" height="283" width_o="1280" height_o="283" data-src="https://freight.cargo.site/t/original/i/6b7a145e397e5971cb788fff02bdeef12ac239e8b3dd50b451350b1139971a07/1280px-University_of_Southampton_Logo.png" data-mid="38992024" border="0" data-scale="22" src="https://freight.cargo.site/w/1000/i/6b7a145e397e5971cb788fff02bdeef12ac239e8b3dd50b451350b1139971a07/1280px-University_of_Southampton_Logo.png" />&nbsp; &nbsp; &nbsp;<img width="421" height="120" width_o="421" height_o="120" data-src="https://freight.cargo.site/t/original/i/9cbe83f75c9c1f453c33df639c1896c8e36b63e1bf120a486599fe3a50886fe1/Unknown.png" data-mid="38991944" border="0" data-scale="20" src="https://freight.cargo.site/w/421/i/9cbe83f75c9c1f453c33df639c1896c8e36b63e1bf120a486599fe3a50886fe1/Unknown.png" /> &nbsp;Scale of the problem&nbsp; The problem of antimicrobial resistance (AMR) is augmented by other contributing factors, in India. <img width="4267" height="3080" width_o="4267" height_o="3080" data-src="https://freight.cargo.site/t/original/i/c2e6b4a4dac5ac45722e265c45c0fb38283280e3996dcf046de916ddb423ef9b/DOSA_Diagrams-07.jpg" data-mid="37844804" border="0" src="https://freight.cargo.site/w/1000/i/c2e6b4a4dac5ac45722e265c45c0fb38283280e3996dcf046de916ddb423ef9b/DOSA_Diagrams-07.jpg" /><img width="4268" height="3080" width_o="4268" height_o="3080" data-src="https://freight.cargo.site/t/original/i/418bf8fc882ad6207a2210a9e00c503fd424c383ffe3552da618077650c4e54b/Diagrams-05.1-05.jpg" data-mid="38989407" border="0" src="https://freight.cargo.site/w/1000/i/418bf8fc882ad6207a2210a9e00c503fd424c383ffe3552da618077650c4e54b/Diagrams-05.1-05.jpg" /> <img width="4267" height="3081" width_o="4267" height_o="3081" data-src="https://freight.cargo.site/t/original/i/0d255848834f844c923ca7dd74602ee8d6f51ed8468f926092736b59f09378fa/DOSA_Diagrams-08.jpg" data-mid="37844807" border="0" src="https://freight.cargo.site/w/1000/i/0d255848834f844c923ca7dd74602ee8d6f51ed8468f926092736b59f09378fa/DOSA_Diagrams-08.jpg" /> &nbsp;Locations&nbsp; <img width="4268" height="3067" width_o="4268" height_o="3067" data-src="https://freight.cargo.site/t/original/i/540dd9d4d64099c9b252d02f4dd4dfe9e0abb69e225ee3eb9b98f2c1024c4573/DOSA_Diagrams-06.jpg" data-mid="37844809" border="0" src="https://freight.cargo.site/w/1000/i/540dd9d4d64099c9b252d02f4dd4dfe9e0abb69e225ee3eb9b98f2c1024c4573/DOSA_Diagrams-06.jpg" /> &nbsp;Partners&nbsp;Our partners include:Click logo to find out more <img width="200" height="213" width_o="200" height_o="213" data-src="https://freight.cargo.site/t/original/i/2c74839ada0f09ddc88c706c7f455682ba9664cafa3fdea503671cd55d22c72b/assam.png" data-mid="33917574" border="0" data-scale="10" src="https://freight.cargo.site/w/200/i/2c74839ada0f09ddc88c706c7f455682ba9664cafa3fdea503671cd55d22c72b/assam.png" />&nbsp;<img width="225" height="225" width_o="225" height_o="225" data-src="https://freight.cargo.site/t/original/i/02109e8d1166f2c2a1b713e5b81835f08f5af9e03a7cb2085b99eccf31694096/CIFT.jpg" data-mid="33917576" border="0" data-scale="10" src="https://freight.cargo.site/w/225/i/02109e8d1166f2c2a1b713e5b81835f08f5af9e03a7cb2085b99eccf31694096/CIFT.jpg" />&nbsp;<img width="215" height="220" width_o="215" height_o="220" data-src="https://freight.cargo.site/t/original/i/fdcb912db08434c040698ae57a3b5957bbf8b7cd9514cf0d4b2be687040fb57a/ndri.png" data-mid="33917578" border="0" data-scale="10" src="https://freight.cargo.site/w/215/i/fdcb912db08434c040698ae57a3b5957bbf8b7cd9514cf0d4b2be687040fb57a/ndri.png" />&nbsp;<img width="224" height="225" width_o="224" height_o="225" data-src="https://freight.cargo.site/t/original/i/a6ca8df03b9a7e3504e5929db6afffac2c1e9686d9fc925b316bf303ec89689a/UOE.png" data-mid="33917582" border="0" data-scale="10 " src="https://freight.cargo.site/w/224/i/a6ca8df03b9a7e3504e5929db6afffac2c1e9686d9fc925b316bf303ec89689a/UOE.png" /> <img width="220" height="165" width_o="220" height_o="165" data-src="https://freight.cargo.site/t/original/i/c0aca5016c359620593825199a45ba17903afe2e2601a1de5f6c3b1c807d8308/iitd.jpg" data-mid="33917577" border="0" data-scale="13" src="https://freight.cargo.site/w/220/i/c0aca5016c359620593825199a45ba17903afe2e2601a1de5f6c3b1c807d8308/iitd.jpg" /><img width="205" height="246" width_o="205" height_o="246" data-src="https://freight.cargo.site/t/original/i/21944759b5b28679838d376702d053d0717b9843957abd37c7c91aca2a94f91b/SMC.jpg" data-mid="33917579" border="0" data-scale="8" src="https://freight.cargo.site/w/205/i/21944759b5b28679838d376702d053d0717b9843957abd37c7c91aca2a94f91b/SMC.jpg" /> &nbsp;<img width="339" height="149" width_o="339" height_o="149" data-src="https://freight.cargo.site/t/original/i/2b005f87951e3a73d9b32344df9281ebc7d8673da1485483e0cda5f68c705190/CAMP.jpg" data-mid="33917575" border="0" data-scale="20" src="https://freight.cargo.site/w/339/i/2b005f87951e3a73d9b32344df9281ebc7d8673da1485483e0cda5f68c705190/CAMP.jpg" /> <img width="800" height="202" width_o="800" height_o="202" data-src="https://freight.cargo.site/t/original/i/e5c3072c6c13a39e654bb7ea7aa4e79525a9cc4771c382bd7c8ad1f76d58a363/uob_logo_rgb_positive_large.jpg" data-mid="38992033" border="0" data-scale="21" src="https://freight.cargo.site/w/800/i/e5c3072c6c13a39e654bb7ea7aa4e79525a9cc4771c382bd7c8ad1f76d58a363/uob_logo_rgb_positive_large.jpg" />&nbsp; &nbsp; &nbsp;<img width="1280" height="283" width_o="1280" height_o="283" data-src="https://freight.cargo.site/t/original/i/6b7a145e397e5971cb788fff02bdeef12ac239e8b3dd50b451350b1139971a07/1280px-University_of_Southampton_Logo.png" data-mid="38992024" border="0" data-scale="22" src="https://freight.cargo.site/w/1000/i/6b7a145e397e5971cb788fff02bdeef12ac239e8b3dd50b451350b1139971a07/1280px-University_of_Southampton_Logo.png" />&nbsp; &nbsp; &nbsp;<img width="421" height="120" width_o="421" height_o="120" data-src="https://freight.cargo.site/t/original/i/9cbe83f75c9c1f453c33df639c1896c8e36b63e1bf120a486599fe3a50886fe1/Unknown.png" data-mid="38991944" border="0" data-scale="20" src="https://freight.cargo.site/w/421/i/9cbe83f75c9c1f453c33df639c1896c8e36b63e1bf120a486599fe3a50886fe1/Unknown.png" /> https://dosa-diagnostics.org/News Mon, 23 Nov 2020 17:16:05 +0000 dosa-diagnostics https://dosa-diagnostics.org/News <img width="5184" height="1085" width_o="5184" height_o="1085" data-src="https://freight.cargo.site/t/original/i/678e600c07116fc44959f149958191303d3dee137d040ab5785762f7ce279d89/news.jpg" data-mid="89818454" border="0" src="https://freight.cargo.site/w/1000/i/678e600c07116fc44959f149958191303d3dee137d040ab5785762f7ce279d89/news.jpg" /> &nbsp;News&nbsp; Diagnostics to Combat AMR in Aquaculture29/09/2021 Watch our updated animation on the role of diagnostics in combatting AMR in Indian aquaculture. Detection of the antibiotic residues at the farm and system level will help decision making and build confidence. Available in Malayalam and English.&nbsp; DOSA DPA Test Kit Shrimp Demonstration 11/07/2021 Watch technical demonstrations of the DOSA DPA Test Kit being used to identify antibiotic residue in shrimp samples in the lab.&nbsp; Antibiotic Residue Test for Shrimp 11/07/2021 Watch our new animation to see how the DOSA DPA Test Kit can support shrimp farmers with more confidence in their shrimp quality and better understanding of antibiotic contamination points in their area&nbsp; Aquaculture15/12/2020 Dr. G.K. Sivaraman, Professor Alison Prendiville and Dr. Ravikrishnan Elangovan talk about DOSA activities undertaken in designing diagnostics to manage AMR within the aquaculture setting in India. The Three Settings 02/12/2020 Professor Till T Bachmann describes the rationale behind the focus of DOSA’s three contextual settings: urinary tract infections in human health, mastitis in dairy for animal health, and the shrimp aquaculture supply chain for the environmental setting. AMR and Diagnostics 25/11/2020 In our second video of the DOSA Perspective Series, our joint co-ordinators, Till T. Bachmann and Ravi Krishnan Elangovan, give a brief description into what antimicrobial resistance is and the role of diagnostics in addressing the challenges of AMR in India.&nbsp; Welcome to the DOSA Perspectives series 23/11/2020 Following the launch of our Overview video, released to mark our support in the campaigns of the European Antibiotic Awareness Week and the WHO's World AMR Awareness Week 2020, DOSA is pleased to share the first DOSA Perspectives video. It opens a series of short videos of our insights around One Health, diagnostics, and AMR in India. We begin with an introduction video from Till T. Bachmann, University of Edinburgh, and Ravi Krishnan Elangovan, Indian Institute of Technology Delhi, the joint co-ordinators for the project. Stay tuned for more videos on our website and we hope you enjoy our DOSA Perspectives series. “Antimicrobials: Handle with Care” 18/11/2020 To coincide with the WHO’s World Antimicrobial Awareness Week 2020 and European Antibiotic Awareness Day 2020, we are delighted to share the DOSA introductory video, encapsulating our project aim of developing Diagnostics for One Health and User Driven Solutions for AMR ('DOSA'). Through this video, and our ongoing DOSA project, we aim to raise awareness around better decision making relating to antimicrobial usage, and the different ways of tackling the global challenges of AMR. You can view the video here: Throughout 2019, DOSA conducted a series of field visits, undertaking site observations, semi-structured interviews and focus group co-design sessions in India, to capture the local practices and knowledge around urinary tract infections (UTI) in human health, mastitis in dairy cows and antibiotic residues in aquaculture. Concurrent to these design ethnography activities, baseline assessments were conducted to provide us with an overview of the current microbiological and AMR situation in each setting. In the meantime, our diagnostic innovator teams developed a large toolbox of cutting edge diagnostic technology elements which will be adapted and combined to meet the user requirements in the settings. Human health Analysis of urine samples from patients at Primary Healthcare Centers (PHCs) identified a range of resistant bacteria shedding light on the burden of AMR and UTI in the community. In parallel, conversations were held with community members, ASHAs (Accredited Social Health Activists), pharmacists and PHC staff, revealing the need for recognising infection at a community level and breaking down barriers around understanding UTI symptoms and treatments. <img width="4272" height="2848" width_o="4272" height_o="2848" data-src="https://freight.cargo.site/t/original/i/92a0dc2da02b92ce413a32c6deb25e3c6c4d12c004a681976a1908960f57e38d/IMG_6097.JPG" data-mid="89818466" border="0" src="https://freight.cargo.site/w/1000/i/92a0dc2da02b92ce413a32c6deb25e3c6c4d12c004a681976a1908960f57e38d/IMG_6097.JPG" /><img width="4272" height="2848" width_o="4272" height_o="2848" data-src="https://freight.cargo.site/t/original/i/df67503b495c2e34b16197f1269b03e825eae86e1c9411b1128552683e5a4298/IMG_6317.JPG" data-mid="89818467" border="0" src="https://freight.cargo.site/w/1000/i/df67503b495c2e34b16197f1269b03e825eae86e1c9411b1128552683e5a4298/IMG_6317.JPG" /> Dairy The team engaged with farm workers from backyard&nbsp; and organised dairy farms, para-vets, veterinary practitioners, pharmacists and dairy processing plants. Raw milk samples from dairy farms were analysed, highlighting a broad range of mastitis cases, the presence of antibiotic residues, and drug resistant pathogens, such as E.coli and S. aureus. These activities emphasized the need for identifying the presence of mastitis and its treatment at farm level, alongside having better knowledge around selling milk that is free from antibiotic residue. <img width="4272" height="2848" width_o="4272" height_o="2848" data-src="https://freight.cargo.site/t/original/i/f5e37106336fe368d7b30cf7688c29de28e59a8b6f4a501afe9106f2e9dbbfd3/IMG_6676.JPG" data-mid="89818468" border="0" src="https://freight.cargo.site/w/1000/i/f5e37106336fe368d7b30cf7688c29de28e59a8b6f4a501afe9106f2e9dbbfd3/IMG_6676.JPG" /> <img width="4272" height="2848" width_o="4272" height_o="2848" data-src="https://freight.cargo.site/t/original/i/3ed199f3ac1d9d6e71f64acc889a42c63208167952758e34dedba7dc34c54479/IMG_6686.JPG" data-mid="89818469" border="0" src="https://freight.cargo.site/w/1000/i/3ed199f3ac1d9d6e71f64acc889a42c63208167952758e34dedba7dc34c54479/IMG_6686.JPG" /> Aquaculture Interacting with traditional and scientific farmers, processing plants, private diagnostics labs, hatcheries and state officials, opened up conversations around increasing trust in transactions between stakeholders, and enhancing the farmer registration process and quality control across the supply chain. The assessment of samples from pond water, sediment and shrimps identified some prevalence of relevant bacteria as well as antimicrobial resistance genes underpinning the need for diagnostics in the aquaculture setting. <img width="3264" height="2448" width_o="3264" height_o="2448" data-src="https://freight.cargo.site/t/original/i/6cea9a582a9f76f78b89d55646c26b80399b27cac3b1e6ef3fbd5fdb9e994306/IMG_8060.JPG" data-mid="89818472" border="0" src="https://freight.cargo.site/w/1000/i/6cea9a582a9f76f78b89d55646c26b80399b27cac3b1e6ef3fbd5fdb9e994306/IMG_8060.JPG" /><img width="4272" height="2848" width_o="4272" height_o="2848" data-src="https://freight.cargo.site/t/original/i/1e5baac6666ab5216ff2a9edf881499b770aa6057d256677f5cdc6f7379737ec/IMG_7037.JPG" data-mid="89818471" border="0" src="https://freight.cargo.site/w/1000/i/1e5baac6666ab5216ff2a9edf881499b770aa6057d256677f5cdc6f7379737ec/IMG_7037.JPG" /> Contextualising AMR for diagnostics opportunities Engaging with end-users and having an overview of pathogens, resistant genes and antibiotic residues, enabled us to reflect upon the social, and microbiological opportunities for diagnostic technology services. In summary, the baseline assessment and design and ethnography activities of year one have elicited the following values for diagnostics and testing across the three settings: – Point of care identification of infections and treatment – Better understanding around antimicrobial usage – Enhanced recording and knowledge around the health of one’s own body, livestock, or farm; – Raising the quality of Indian dairy and shrimp products, for both domestic and exporting markets. These values have shaped the development of Target Product Profiles in DOSA, driving the further development and prototyping of diagnostics across the three settings, taking place in 2021. <img width="4272" height="2848" width_o="4272" height_o="2848" data-src="https://freight.cargo.site/t/original/i/bb0e5dab466451dd922d98c1815b7f31f2923fe92b25081c645135aa7e5be051/IMG_7360.JPG" data-mid="89818464" border="0" src="https://freight.cargo.site/w/1000/i/bb0e5dab466451dd922d98c1815b7f31f2923fe92b25081c645135aa7e5be051/IMG_7360.JPG" /><img width="4272" height="2848" width_o="4272" height_o="2848" data-src="https://freight.cargo.site/t/original/i/880745241476298941f01e8e9317a9bfd8fcc8a087f06d827096a5ba44c0447d/IMG_7453.JPG" data-mid="89818465" border="0" src="https://freight.cargo.site/w/1000/i/880745241476298941f01e8e9317a9bfd8fcc8a087f06d827096a5ba44c0447d/IMG_7453.JPG" /> https://dosa-diagnostics.org/Indian-Institute-of-Technology-Delhi Mon, 04 Mar 2019 12:38:53 +0000 dosa-diagnostics https://dosa-diagnostics.org/Indian-Institute-of-Technology-Delhi <img width="5184" height="1085" width_o="5184" height_o="1085" data-src="https://freight.cargo.site/t/original/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" data-mid="36778907" border="0" src="https://freight.cargo.site/w/1000/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" /> <img width="220" height="165" width_o="220" height_o="165" data-src="https://freight.cargo.site/t/original/i/c0aca5016c359620593825199a45ba17903afe2e2601a1de5f6c3b1c807d8308/iitd.jpg" data-mid="36778881" border="0" src="https://freight.cargo.site/w/220/i/c0aca5016c359620593825199a45ba17903afe2e2601a1de5f6c3b1c807d8308/iitd.jpg" />Key People Ravikrishnan Elangovan, Associate Professor, Department of Biochemical Engg and Biotechnology, Indian Institute of Technology, Delhi. http://web.iitd.ac.in/~elangovan/ Ravi is a biophysicist by training, is actively engaged in developing methods/technologies for visualizing biological systems. Ravi and his team have developed four platform technologies for infectious disease diagnosis. He is founder director for Valetuprimus Healthcare Pvt LTd, spinoff from his lab. He is keen to develop technologies to identify pathogens and drug susceptibility with a faster turnaround time in low resource settings. Government funded Engineering Institute www.iitd.ac.in <img width="540" height="574" width_o="540" height_o="574" data-src="https://freight.cargo.site/t/original/i/70fcb2eafdfac3079e68ff4cf30f654176ea78866ef32dd94cef5f4a416d78d2/Screenshot-2019-03-17-at-18.10.35.png" data-mid="37847336" border="0" data-scale="44" src="https://freight.cargo.site/w/540/i/70fcb2eafdfac3079e68ff4cf30f654176ea78866ef32dd94cef5f4a416d78d2/Screenshot-2019-03-17-at-18.10.35.png" /> https://dosa-diagnostics.org/University-of-Southampton Sun, 17 Mar 2019 18:05:21 +0000 dosa-diagnostics https://dosa-diagnostics.org/University-of-Southampton <img width="5184" height="1085" width_o="5184" height_o="1085" data-src="https://freight.cargo.site/t/original/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" data-mid="37847152" border="0" src="https://freight.cargo.site/w/1000/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" /> <img width="1280" height="283" width_o="1280" height_o="283" data-src="https://freight.cargo.site/t/original/i/63fcbe11f30396dad378256f120101e99e3de96413b83a93fcdd52c1dd65dbc4/1280px-University_of_Southampton_Logo.png" data-mid="37847982" border="0" data-scale="67" src="https://freight.cargo.site/w/1000/i/63fcbe11f30396dad378256f120101e99e3de96413b83a93fcdd52c1dd65dbc4/1280px-University_of_Southampton_Logo.png" /> University of Southampton is a world-class research-intensive Russel Group university with a world-leading and internationally excellent research portfolio. https://www.southampton.ac.uk/ Key People&nbsp; Prof Xunli Zhang is Professor of Bioengineering and Microsystems, and Deputy Director of Graduate School, in the Faculty of Engineering and Physical Sciences, University of Southampton. His key expertise lies in the area of microfluidic and Lab-on-a-Chip technologies, and the application in bioengineering, in particular, related to cell-based bioanalysis, drug delivery systems and biomicrofluidics. The application is largely associated with therapeutic problems like patient specific design of microfluidic devices for cancer treatment, rapid diagnosis of drug allergy, and more recently, addressing AMR in tuberculosis. <img width="494" height="704" width_o="494" height_o="704" data-src="https://freight.cargo.site/t/original/i/c487a705a1130568184c12f2c7a0f74dce65f068a21f00590c10c9673381e4da/Screenshot-2019-03-17-at-18.13.35.png" data-mid="37847448" border="0" data-scale="36" src="https://freight.cargo.site/w/494/i/c487a705a1130568184c12f2c7a0f74dce65f068a21f00590c10c9673381e4da/Screenshot-2019-03-17-at-18.13.35.png" /> https://dosa-diagnostics.org/UAL Sun, 17 Mar 2019 18:04:48 +0000 dosa-diagnostics https://dosa-diagnostics.org/UAL <img width="5184" height="1085" width_o="5184" height_o="1085" data-src="https://freight.cargo.site/t/original/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" data-mid="37846983" border="0" src="https://freight.cargo.site/w/1000/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" /> <img width="421" height="120" width_o="421" height_o="120" data-src="https://freight.cargo.site/t/original/i/d9f51eb8da65bede105dcce68dc667f23791193b30a0d025586edd2aecd95316/Unknown.png" data-mid="37848099" border="0" src="https://freight.cargo.site/w/421/i/d9f51eb8da65bede105dcce68dc667f23791193b30a0d025586edd2aecd95316/Unknown.png" /> UAL is Europe’s largest specialist Arts and Design University, bringing together six arts, design, fashion and communication Colleges. The university actively engages in interdisciplinary research and innovation as well as artistic, cultural and education projects both nationally and internationally. &nbsp;UAL is at the forefront of developing the field of social design, designing for service and design for policy that reflects its expertise for DOSA. UAL has a reputation for defining how professional design practice can and should respond to contemporary global challenges, social inequalities and sustainable futures.&nbsp; The London College of Communication (LCC) is made up of world-renowned practitioners and theorists specialising in film, current practices and histories of photography, interaction design, service design, sound arts, graphic and information design. As a pioneer of one of the first UK Service Design courses, the College was an earlier adopter of co-design methods and tools to engage diverse communities and stakeholders in human-centred approaches to a range of health and social care settings. University, Government body https://www.arts.ac.uk/ Key People&nbsp; Dr Alison Prendiville is Professor of Service Design at LCC University of the Arts London. She collaborates with designers, healthcare professionals, scientists, engineers, and ethnographers to facilitate and converge science and technology with design for the development of new products, services, and processes. Within this interdisciplinary frame, her research and practice include design’s role in service transformation for the public sector in both local government and health care contexts. She is currently working with microbiologists and healthcare practitioners in the area of antimicrobial resistance in India (ESRC), and in the UK (AHRC), and engaging the public in the co-creation of knowledge to better understand acceptance and barriers to new plant breeding techniques in the development of pharmaceuticals (EU Horizon 2020). Her work has been published in books and journals including Designing for Health, Gower publishing (2017) and Design Issues. She has recently edited with Daniela Sangiorgi ‘Designing for Service: Key Issues and New Directions, published by Bloomsbury (2017). <img width="502" height="664" width_o="502" height_o="664" data-src="https://freight.cargo.site/t/original/i/2a8965b463cf9f1c3db9a07bcff23c1e46deb6c1ea287e133b95561e7df02be5/Screenshot-2019-03-17-at-18.17.48.png" data-mid="37848093" border="0" data-scale="44" src="https://freight.cargo.site/w/502/i/2a8965b463cf9f1c3db9a07bcff23c1e46deb6c1ea287e133b95561e7df02be5/Screenshot-2019-03-17-at-18.17.48.png" /> https://dosa-diagnostics.org/Bradford Sun, 17 Mar 2019 18:05:35 +0000 dosa-diagnostics https://dosa-diagnostics.org/Bradford <img width="5184" height="1085" width_o="5184" height_o="1085" data-src="https://freight.cargo.site/t/original/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" data-mid="37847228" border="0" src="https://freight.cargo.site/w/1000/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" /> <img width="800" height="202" width_o="800" height_o="202" data-src="https://freight.cargo.site/t/original/i/c41737ac95e6e3ea7f36eacfe1e42c54f4d7ec02b45eefed4791936a1df89846/uob_logo_rgb_positive_large.jpg" data-mid="37848191" border="0" data-scale="61" src="https://freight.cargo.site/w/800/i/c41737ac95e6e3ea7f36eacfe1e42c54f4d7ec02b45eefed4791936a1df89846/uob_logo_rgb_positive_large.jpg" /> The Polymer and Biomaterials Chemistry Laboratories (PBCL) are part of the School of Chemistry and Biosciences at the University of Bradford. The Centre delivers both research and teaching in the synthesis, characterisation, chemical modelling and properties of polymers. Funded by industrial and UKRI grants PBCL is one of the leading UK Centres in the field and within the interdisciplinary centre for polymer science and technology represents one of the largest consortia of Polymer expertise in Europe.&nbsp; Key People Stephen Rimmer is Professor of Chemistry. He was awarded a PhD in 1992 (Imperial College) for work on polyurethanes. He spent a total of six years in industrial research and development and two years as a post-doctoral fellow with Prof. J. R. Ebdon. His time in industry included development of many commercialised coatings and a new contact lens. He has spent time as an academic at Lancaster University and at the University of Sheffield, as the Chair of Polymer Chemistry. In 2015 he took up the Chair of Chemistry at Bradford. His research involves the synthesis and biological applications of polymers. He has been awarded over £6 million in funding from various research councils, charities and industrial concerns. He has published 132 peer-reviewed articles and 12 book chapters and reviews and is inventor on 14 filed patents. &nbsp;He was also founding chair of RSC’s special interest group in Biomaterials Chemistry. <img width="328" height="462" width_o="328" height_o="462" data-src="https://freight.cargo.site/t/original/i/9e14904d80872f31c0667cd69a55662b4dec3af893eab851717fe5f6d9e8415d/Screenshot-2019-04-01-at-18.23.06.png" data-mid="38986492" border="0" data-scale="35" src="https://freight.cargo.site/w/328/i/9e14904d80872f31c0667cd69a55662b4dec3af893eab851717fe5f6d9e8415d/Screenshot-2019-04-01-at-18.23.06.png" /> https://dosa-diagnostics.org/Edinburgh Sun, 17 Mar 2019 18:05:08 +0000 dosa-diagnostics https://dosa-diagnostics.org/Edinburgh <img width="5184" height="1085" width_o="5184" height_o="1085" data-src="https://freight.cargo.site/t/original/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" data-mid="37847081" border="0" src="https://freight.cargo.site/w/1000/i/146fea17580840a7f7b952a9505d2c63ccdd579b9965f2fff7cc1a8e5b2c4071/louis-reed-747388-unsplash_long3-copy.jpg" /> <img width="831" height="199" width_o="831" height_o="199" data-src="https://freight.cargo.site/t/original/i/0bee7fd60f9404a4cf6d89e7c49ba3923f0b722fcc8f7b698a46177538494773/logo.png" data-mid="37847091" border="0" data-scale="76" src="https://freight.cargo.site/w/831/i/0bee7fd60f9404a4cf6d89e7c49ba3923f0b722fcc8f7b698a46177538494773/logo.png" />The University of Edinburgh is one of the largest and most successful universities in the UK with an international reputation as a centre of academic excellence. The University is the leading research university in Scotland and is amongst the top ten in the United Kingdom and amongst the top ranked universities globally. It is the University's stated aim that it wishes as far as possible to conduct its research and development activities on a trans-national basis. The pooling of research expertise, equipment and database resources contributes to major advances in science, technology and medicine worldwide. The College of Medicine and Veterinary Medicine traces its origins back nearly 500 years and is internationally renowned for its research and teaching and has the only conjoint Medical and Veterinary Medical School in the UK. The Division of Infection and Pathway Medicine is a research centre in the Edinburgh Medical School and focussed on precision medicine, genomic science, systems biology of infectious diseases. DIPM is part of the 20-30 core PI Infection Medicine Cluster at the Edinburgh BioQuarter and the 860 Scientist Edinburgh Infectious Diseases network across the city of Edinburgh. Key People Professor Till T Bachmann is Deputy Head of the Infection Medicine ,Personal Chair of Molecular Diagnostics and Infection. , Programme Director of the Clinical Microbiology &amp; Infectious Diseases MSc at The University of Edinburgh and University of Edinburgh Director of the Zhejiang University - University of Edinburgh Institute Dual PhD programme. Till has a PhD in biosensor research from the University of Stuttgart and The University of Tokyo, as well as a German Habilitation in Analytical Biotechnology. He is an expert in the Point-of-Care detection of infectious diseases and antimicrobial resistance, conducting research at the interface of biomarkers and novel detection modalities. Till gained commercial experience as a founding CEO of Namaxx Genomic GmbH (2001-6) and as Scientific Programme Director for MHC Scotland Ltd (2013-15). He also fulfils a variety of industrial and institutional advisory roles worldwide.For DOSA he brings in a range of relevant activities and memberships, such as the UK Five Year National AMR Strategy: AMR Diagnostic Collaborative, panel member for UK Longitude Prize Panel, Scottish Universities Life Science Alliance AMR Steering Group, Scientific Advisory Board member of CARB-X, Vice-Chair of the JPIAMR Scientific Advisory Board, AMR Strategy Lead for Edinburgh Infectious Diseases, founder Edinburgh AMR Forum, Edinburgh Global Health Academy and Global Security Steering Groups. Till was also judge for the EU Horizon Prize on Better Use of Antibiotics (2016) and is member of the Devices and Diagnostics Advisory Board for BIRAC/Indian Government, the founder of AMR DxC, the Antimicrobial Resistance Diagnostics Challenge competition. <img width="855" height="1100" width_o="855" height_o="1100" data-src="https://freight.cargo.site/t/original/i/a055a413b07ef0e2da4a990ec22fc1e512065e27fbe826d28211266381b164f7/Till_Bachmann.jpg" data-mid="37847092" border="0" data-scale="44" src="https://freight.cargo.site/w/855/i/a055a413b07ef0e2da4a990ec22fc1e512065e27fbe826d28211266381b164f7/Till_Bachmann.jpg" /> Key People&nbsp; Dominic Moran, Professor of Agricultural and Resource Economics,&nbsp;Global Academy of Agriculture and Food Security,&nbsp; The Royal (Dick) School of Veterinary Studies and The Roslin Institute,&nbsp; Easter Bush Campus, Midlothian, EH25 9RG. Representing numerous academic departments under the umbrella of University of Edinburgh Global Academy of Agriculture and Food Security&nbsp; https://www.ed.ac.uk/global-agriculture-food-security; and Edinburgh Infectious Diseases, which is a large network of infectious disease researchers and clinicians in Edinburgh https://www.ed.ac.uk/edinburgh-infectious-diseases/about <img width="1008" height="1006" width_o="1008" height_o="1006" data-src="https://freight.cargo.site/t/original/i/fbdc61b881724289935eca083453b04d91961315a502baeee3741f19e347730a/Screenshot-2019-04-14-at-12.15.42.png" data-mid="39978881" border="0" data-scale="39" src="https://freight.cargo.site/w/1000/i/fbdc61b881724289935eca083453b04d91961315a502baeee3741f19e347730a/Screenshot-2019-04-14-at-12.15.42.png" /> Key People Dr Holger Schulze is a Senior Research Fellow at the Division of Infection and Pathway Medicine of the University of Edinburgh Medical School with more than 15 years of experience in academia and 3 years in industry in molecular diagnostics, point-of-care test development and biosensor research including electrochemical impedance spectroscopy and amperometric enzyme biosensors, sensor development, and electrochemical DNA, RNA as well as protein detection. He is an experienced researcher in multi-disciplinary teams working on the development of diagnostic biosensor platforms for antimicrobial resistance, infectious diseases and microRNA detection. Holger received a PhD in biosensors from research at the Institute of Technical Biochemistry of the University of Stuttgart in Germany in 2003. Between 2012 and 2015 he gained industrial experience as a diagnostic biosensor development scientist at Mölnlycke Health Care Scotland in Edinburgh where he was part of the development of a MRSA point-of-care test in an ISO 13485 certified company. <img width="1008" height="998" width_o="1008" height_o="998" data-src="https://freight.cargo.site/t/original/i/59260d782fa232d95cbccd23f080df13523845760dfaa8302d4f84fdbd1c50e9/Screenshot-2019-04-14-at-12.26.50.png" data-mid="39979068" border="0" data-scale="36" src="https://freight.cargo.site/w/1000/i/59260d782fa232d95cbccd23f080df13523845760dfaa8302d4f84fdbd1c50e9/Screenshot-2019-04-14-at-12.26.50.png" /> Key People Investigating Diagnostic Devices in Global Health Dr Alice Street is a Senior Lecturer at the School of Social and Political Science at the University of Edinburgh. Dr Street is an anthropologist with the School of Social and Political Science at the University of Edinburgh.&nbsp;She is the&nbsp;Principal Investigator of a&nbsp;European Research Council funded project on diagnostic devices in global health.&nbsp;The DiaDev project, Investigating the Design and Use of Diagnostic Devices in Global Health, explores the emergent role that diagnostic devices are playing in the transformation of global health partnerships and national health systems in low and middle-income countries. Drawing on novel conceptual and methodological tools from social anthropology, it investigates the social, cultural and technical processes involved in developing, deploying and using diagnostic devices in resource-limited settings. The goal of the project is to guide global health policy through improving our understanding of relationships between technological innovation and the&nbsp;strengthening of health systems. <img width="454" height="582" width_o="454" height_o="582" data-src="https://freight.cargo.site/t/original/i/06db38821e526e97290905a46bf868db6233df468bd9825a274805914394c075/Screenshot-2019-04-18-at-17.52.50.png" data-mid="40349213" border="0" data-scale="39" src="https://freight.cargo.site/w/454/i/06db38821e526e97290905a46bf868db6233df468bd9825a274805914394c075/Screenshot-2019-04-18-at-17.52.50.png" /> &nbsp; https://dosa-diagnostics.org/Our-Disciplines Mon, 28 Jan 2019 12:26:01 +0000 dosa-diagnostics https://dosa-diagnostics.org/Our-Disciplines <img width="5184" height="1085" width_o="5184" height_o="1085" data-src="https://freight.cargo.site/t/original/i/e2a43e02d62e58e60044971c9abfcf28f5d76b2bec4ef2351bc840c225cec781/louis-reed-747388-unsplash_long4-copy.jpg" data-mid="34491729" border="0" src="https://freight.cargo.site/w/1000/i/e2a43e02d62e58e60044971c9abfcf28f5d76b2bec4ef2351bc840c225cec781/louis-reed-747388-unsplash_long4-copy.jpg" /> &nbsp;Our Disciplines&nbsp;Rationale Unwarranted consumption of antibiotics in human health care setting and animal agriculture has been a major driver for antibiotic resistance. Lack of appropriate diagnostic technologies and associated services at the community settings has been a major bottleneck. The aim of DOSA is to develop a user-driven, one health approach to the creation of diagnostics services, to better manage the use of antibiotics in community healthcare, dairy, and aqua culture settings. This work draws on social science, design research and service design to map and reveal every day practices around the use of antibiotics and diagnostics within the three settings and to collaboratively engage local communities in the co-design of diagnostic interventions. The development and implementation of diagnostics technologies should involve a comprehensive range of potential users so that the resulting diagnostic services are user driven and configured to reflect the specific social and cultural contexts. To achieve this the DOSA project will be applying a combination of research practices to consider all the people affected by the potential diagnostic services. Rather than being technology led, a range of qualitative research methods will be used to inform the development of the functional and service elements of the assays through the definition of Target Product Profiles with the active engagement of the local communities. <img width="4267" height="3080" width_o="4267" height_o="3080" data-src="https://freight.cargo.site/t/original/i/6d5207880a8c68e3f29d0bf5430900df1e71fc4ee6b13c012fe43f4c78e94a90/DOSA_Diagrams-01.jpg" data-mid="37844719" border="0" src="https://freight.cargo.site/w/1000/i/6d5207880a8c68e3f29d0bf5430900df1e71fc4ee6b13c012fe43f4c78e94a90/DOSA_Diagrams-01.jpg" />&nbsp;Service Design&nbsp;Rapid Ethnography Assessment will be used in the first instance to capture daily practices around antibiotic prescribing, use and testing for infections in human, dairy farms and aqua culture. From this initial data collection, more in-depth design ethnography will be undertaken at selected sites to map and engage community members in discussions around their lives as lived and their everyday encounters with antibiotics. Visual tools and probes will be specifically developed to initiate conversations to reflect and map current practices at the three different settings. In addition, service design methods, framed within the Design Councils (2005) Double Diamond model will take the data collection through iterative stages of co-design and prototyping with users, to conceptualize possible future diagnostic service scenarios that can be tested in the settings specific environments. <img width="4267" height="3081" width_o="4267" height_o="3081" data-src="https://freight.cargo.site/t/original/i/252a8f3bcc8607a73f552b42c1e5ae1dd339cbd0726ca767e7ae6c86512da869/DOSA_Diagrams-02.jpg" data-mid="37844725" border="0" src="https://freight.cargo.site/w/1000/i/252a8f3bcc8607a73f552b42c1e5ae1dd339cbd0726ca767e7ae6c86512da869/DOSA_Diagrams-02.jpg" /> Concurrently, economic data will be gathered to further map the cost benefit analysis of diagnostics and antibiotic usage, against the user mapping and future diagnostic service scenarios. This will further inform the user led approach by conceptualizing the economic value of the different diagnostic services to different users. &nbsp;Diagnostics part 01&nbsp;Introduction Diagnostics are tools to empower the user to make informed decisions in their respective setting. To make a diagnostic measurement we have the option to analyse different types of samples such as water, food, urine, etc. With our technologies we have the ability to measure in these samples analytes coming from bacteria, people, animals or the antibiotics themselves. Service design will inform which of the technical solutions should be chosen to address the user need which was determined by the ethnographic studies. <img width="4268" height="3081" width_o="4268" height_o="3081" data-src="https://freight.cargo.site/t/original/i/12621716c26cfc891735cb908e6d4d8bf4c78434d56aa8fea8867b6b06703242/Diagrams-04-04.jpg" data-mid="38989728" border="0" src="https://freight.cargo.site/w/1000/i/12621716c26cfc891735cb908e6d4d8bf4c78434d56aa8fea8867b6b06703242/Diagrams-04-04.jpg" />&nbsp;Diagnostics part 02&nbsp;<img width="4268" height="3080" width_o="4268" height_o="3080" data-src="https://freight.cargo.site/t/original/i/6e32a48c92d87b37435ba94a79245a4125bbc8f466bde8f709fea67ffed5c31b/Diagrams-03-03.jpg" data-mid="38989750" border="0" src="https://freight.cargo.site/w/1000/i/6e32a48c92d87b37435ba94a79245a4125bbc8f466bde8f709fea67ffed5c31b/Diagrams-03-03.jpg" /> &nbsp;Baseline Assessment &nbsp;We will back the diagnostic development and service design work by a simultaneous determination of the current status of AMR in the three selected settings. For this we will collect samples such as urine, milk, or water and determine the identity of the bacteria and their antibiotic resistance in these samples. To do this we will use state of the art technologies such as real time PCR, mass spectrometry, and automated culture. We intend also to conduct next generation sequencing and further analyses. These technologies and data will provide the baseline data as well as benchmark tests for the overall DOSA programme. https://dosa-diagnostics.org/Our-Settings Mon, 28 Jan 2019 12:26:30 +0000 dosa-diagnostics https://dosa-diagnostics.org/Our-Settings <img width="5184" height="1085" width_o="5184" height_o="1085" data-src="https://freight.cargo.site/t/original/i/830261682156b588d9138fe7cd627cbdc1a27280823aeb1fa867f3ad48310e06/louis-reed-747388-unsplash_long2.jpg" data-mid="34452363" border="0" data-scale="100" src="https://freight.cargo.site/w/1000/i/830261682156b588d9138fe7cd627cbdc1a27280823aeb1fa867f3ad48310e06/louis-reed-747388-unsplash_long2.jpg" /> &nbsp;Our Settings&nbsp;– To tackle the rising threat of AMR requires a holistic and multi-sectoral perspective known as a One Health approach, as anti-microbials used to treat various infectious diseases in animals may be the same or similar to those used for humans. – DOSA is a One Health approach to AMR with its focus on three settings, of human health, dairy and aquaculture settings. &nbsp;One Health&nbsp; <img width="4267" height="4901" width_o="4267" height_o="4901" data-src="https://freight.cargo.site/t/original/i/bf42e375b923d6c9f24fda29ddb6634d0d894e7800e1ce7293f2b6b8f2acc38a/DOSA_Diagrams-09.jpg" data-mid="37845076" border="0" src="https://freight.cargo.site/w/1000/i/bf42e375b923d6c9f24fda29ddb6634d0d894e7800e1ce7293f2b6b8f2acc38a/DOSA_Diagrams-09.jpg" /> &nbsp;UTIs in Human Health&nbsp;Urinary Tract Infections (UTIs) are increasingly caused by multidrug-resistant organisms as a result of the overuse of empirical, broad-spectrum antibiotic therapy. Increasing drug resistance in bacterial uropathogensis is an important and emerging public health problem. The distribution of antimicrobial susceptibility data of UTI-causing microorganisms changes from place to place. Generally, the antimicrobial treatment is initiated before the culture sensitivity results are available which may lead to the frequent misuse of antibiotics. DOSA will be looking at the opportunities for diagnostics for UTIs in primary health care settings and to develop service scenarios for this test*. *Puneet Bhatt, Rajat Jagani, Praveer Ranjan, Mohd Ashraf Ali Namaji, Rathi. 2017.Antimicrobial Resistance Pattern of Bacterial Isolates from Urinary Tract Infections at a Tertiary Care Centre. Int.J.Curr.Microbiol.App.Sci. 6(1): 175-183.doi: http://dx.doi.org/10.20546/ijcmas.2017.601.022 <img width="4247" height="3076" width_o="4247" height_o="3076" data-src="https://freight.cargo.site/t/original/i/fd5c024b35b4011a2625a1e930006b85d915fc674a59551fc8a5274f82b43b67/DOSA_Diagrams-10.jpg" data-mid="37845077" border="0" src="https://freight.cargo.site/w/1000/i/fd5c024b35b4011a2625a1e930006b85d915fc674a59551fc8a5274f82b43b67/DOSA_Diagrams-10.jpg" />*Pezzlo M. Detection of Urinary Tract Infections by Rapid Methods. Clinical Microbiology Reviews, July 1988, P. 268-280 &nbsp;Mastitis in Dairy Setting&nbsp;Overuse of antimicrobials is considered to be a potentially important driver of AMR. Several strains of S. aureus isolated from mastitis cases have been reported to show resistance against multiple antimicrobials such as penicillin-G, gentamicin, streptomycin, ampicillin, ciprofloxacin, oxytetracycline*. It is recognized that there is a potential role for diagnostics within the service eco- of milk production. DOSA’s user&nbsp;centred approach will identify where diagnostics may have the most meaningful role in managing the use of antibiotics to treat mastitis. *Kumar, R., Yadav, B.R. and Singh, R.S. (2011) Antibiotic resistance and pathogenicity factors in Staphylococcus aureus J. Bio. Sci., 36: 175-188. &nbsp;Economic Impacts of Mastitis in India proach will identif *<img width="4247" height="3076" width_o="4247" height_o="3076" data-src="https://freight.cargo.site/t/original/i/2c09173afecc559e413e6a5b0d04f5310190be5cb9ad3bc0e2c8a057993468ce/Diagrams-11-11-11.jpg" data-mid="39982826" border="0" src="https://freight.cargo.site/w/1000/i/2c09173afecc559e413e6a5b0d04f5310190be5cb9ad3bc0e2c8a057993468ce/Diagrams-11-11-11.jpg" />*Department of Animal Husbandry, Dairying and Fisheries, Ministry of Agriculture, GOI https://www.nddb.coop/information/stats/milkprodstate &nbsp;Antibiotics in Aquaculture&nbsp;The Indian shrimp farming sector has been ranked 4th in global production. With this rapid growth there is also an under appreciation of how aquaculture environments can harbour antibiotic resistant genes and antibiotic resistant bacteria [Cabelloet.al. <img width="4247" height="3238" width_o="4247" height_o="3238" data-src="https://freight.cargo.site/t/original/i/89746822457694c12ee483b7ca9e3ded579d7611cc209220d8f0b51a26637bc4/Diagrams13-13.jpg" data-mid="40849650" border="0" src="https://freight.cargo.site/w/1000/i/89746822457694c12ee483b7ca9e3ded579d7611cc209220d8f0b51a26637bc4/Diagrams13-13.jpg" /> *Cabello et.al. Aquaculture as yet another environmental gateway to the development and globalisation of antimicrobial&nbsp;resistance. Lancet Infect Dis. 2016 Jul;16(7)