Our Settings 

– To tackle the rising threat of AMR requires a holistic and multi-sectoral perspective known as a One Health approach, as anti-microbials used to treat various infectious diseases in animals may be the same or similar to those used for humans.

– DOSA is a One Health approach to AMR with its focus on three settings, of human health, dairy and aquaculture settings.

 One Health 

 UTIs in Human Health 

Urinary Tract Infections (UTIs) are increasingly caused by multidrug-resistant organisms as a result of the overuse of empirical, broad-spectrum antibiotic therapy. Increasing drug resistance in bacterial uropathogensis is an important and emerging public health problem. The distribution of antimicrobial susceptibility data of UTI-causing microorganisms changes from place to place. Generally, the antimicrobial treatment is initiated before the culture sensitivity results are available which may lead to the frequent misuse of antibiotics. DOSA will be looking at the opportunities for diagnostics for UTIs in primary health care settings and to develop service scenarios for this test*.

*Puneet Bhatt, Rajat Jagani, Praveer Ranjan, Mohd Ashraf Ali Namaji, Rathi. 2017.Antimicrobial Resistance Pattern of Bacterial Isolates from Urinary Tract Infections at a Tertiary Care Centre. Int.J.Curr.Microbiol.App.Sci. 6(1): 175-183.doi: http://dx.doi.org/10.20546/ijcmas.2017.601.022

*Pezzlo M. Detection of Urinary Tract Infections by Rapid Methods. Clinical Microbiology Reviews, July 1988, P. 268-280

 Mastitis in Dairy Setting 

Overuse of antimicrobials is considered to be a potentially important driver of AMR. Several strains of S. aureus isolated from mastitis cases have been reported to show resistance against multiple antimicrobials such as penicillin-G, gentamicin, streptomycin, ampicillin, ciprofloxacin, oxytetracycline*. It is recognized that there is a potential role for diagnostics within the service eco- of milk production. DOSA’s user centred approach will identify where diagnostics may have the most meaningful role in managing the use of antibiotics to treat mastitis.

*Kumar, R., Yadav, B.R. and Singh, R.S. (2011) Antibiotic resistance and pathogenicity factors in Staphylococcus aureus J. Bio. Sci., 36: 175-188.

 Economic Impacts of Mastitis in India

proach will identif **Department of Animal Husbandry, Dairying and Fisheries, Ministry of Agriculture, GOI https://www.nddb.coop/information/stats/milkprodstate

 Antibiotics in Aquaculture 

The Indian shrimp farming sector has been ranked 4th in global production. With this rapid growth there is also an under appreciation of how aquaculture environments can harbour antibiotic resistant genes and antibiotic resistant bacteria [Cabelloet.al.

*Cabello et.al. Aquaculture as yet another environmental gateway to the development and globalisation of antimicrobial resistance. Lancet Infect Dis. 2016 Jul;16(7)


© 2019 Dosa Diagnostics. All rights reserved.